Reaction sequence according to the invention
November 20, 2017 09:12
Patent Title: UNIFORM SEQUENCE-DEFINED POLYURETHANES AND USES THEREOF AS MOLECULAR LABELS
Number/Link: WO2017/194694
Applicant/Assignee: Centre National de la Recherche
Publication date: 16 November 2017
“Gist”: Stepwise immobilized polymer synthesis is used to make polyurethane having a predefined sequence of monomers
Why it is interesting: The invention is about monodisperse polyurethanes consisting of a well-defined sequence of monomers having various chain lengths and side groups – not unlike proteins or nucleic acids. In a first step a solid support (e.g. polystyrene beads) which bears a cleavable tether molecule is reacted with N,N’-disuccinimidylcarbonate and in a second step with an aminoalcohol like 5-amino-1-pentanol. Steps 1 and 2 are then repeated using the same or a different aminoalcohol. Finally the tether is cleaved from the support. If 2 different aminoalcohols are used, a binary code can be encoded in the molecule which can later be read using a sequencing technique. The polyurethanes are said to be useful in anti-counterfeiting technologies.
Reaction sequence according to the invention
Posted by Gerhard Bleys
Categories: Uncategorized
Tags: DNA/RNA, HNIPU NIPU, information, molecular label, non-isocyanate polyurethanes, polypeptides, precision polymers, sequencing, stepwise synthesis
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